【摘 要】
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To the Editor:rnHepatitis B immunoglobulin (HBIG) combined with nu- cleos(t)ide analogues (NAs) has become the standard regimen for preventing recurrence of hepatitis B virus (HBV) infection in HBV-related liver transplant (LT) recipients. HBsAg seroposit
【机 构】
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Department of Gastroenterology,the Affiliated Hospital of Qingdao University,Qingdao 266600,China;Di
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To the Editor:rnHepatitis B immunoglobulin (HBIG) combined with nu- cleos(t)ide analogues (NAs) has become the standard regimen for preventing recurrence of hepatitis B virus (HBV) infection in HBV-related liver transplant (LT) recipients. HBsAg seropositivity was detected in only 7.2％–8.6％ of LT recipients who received monotherapy with high-genetic-barrier NAs after a short period of combined therapy [ 1 , 2 ]. Despite progress in the application of newer NAs in HBV-related LT recipients, complete withdrawal of HBV prophylaxis after LT was controversial and considered risky by some centers [3] . We here present two cases of complete and sus- tained HBV cccDNA-negative status after withdrawal of prophylaxis when intrahepatic and active immune response was achieved with hepatitis B vaccination. Our experience provides a strategy for re- liable and safe withdrawal of anti-HBV prophylaxis in HBV-related LT recipients.
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