论文部分内容阅读
目的 探讨caspase 3基因在自然流产滋养细胞中的表达特点。方法 选取临床确诊的自然流产患者的绒毛组织 4 6例 ;选取正常妊娠自愿要求行人工流产者的绒毛 2 0例作为对照组。用免疫组织化学的方法测定各标本中caspase 3基因的表达。结果 caspase 3在绒毛组织的合体滋养细胞和细胞滋养细胞的胞浆中均有表达。caspase 3在自然流产组中的表达明显高于人工流产组 (P <0 0 5 )。结论 滋养细胞中caspase 3基因的表达增高可能是引起自然流产的原因
Objective To investigate the expression of caspase 3 gene in trophoblast cells of spontaneous abortion. Methods Forty-six cases of spontaneous abortion were selected from the clinically diagnosed cases. Twenty cases of villi who underwent voluntary pregnancy were selected as control group. The expression of caspase 3 gene in each specimen was determined by immunohistochemistry. Results Caspase 3 was expressed in the cytoplasm of syncytiotrophoblasts and cytotrophoblasts in chorionic villi. The expression of caspase 3 in spontaneous abortion group was significantly higher than that in induced abortion group (P <0.05). Conclusion The increased expression of caspase 3 in trophoblast may be the reason of spontaneous abortion