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为探讨HBVDNA含量与肝细胞损害关系 ,不加选择采集急、慢性乙肝、肝硬变和肝细胞癌病人入院后和出院前血液标本各 1份 ,同一时间用PCR检测其中HBVDNA的含量拷贝数 ,同时每例在住院期间各做一次肝活检、HE染色观察病理形态 ,分析HBVDNA含量和肝组织病理形态关系。结果 ,血内HBVDNA含量和肝组织炎症病理变化有一致关系 ;同时 ,病程与肝组织内纤维化程度亦有一致性关系。结果提示 ,血内HBVDNA含量在一定程度上可反映出肝组织内炎症轻重 ,抗病毒治疗消除或减少HBVDNA含量是治疗HBV感染不可忽视的问题
In order to explore the relationship between HBVDNA content and hepatocellular damage, we randomly selected 1 acute and chronic hepatitis B, 1 cirrhotic and hepatocellular carcinoma patients and 1 blood sample before discharge. The copy number of HBVDNA was detected by PCR at the same time. Liver biopsy was performed in each case during hospitalization. Pathological changes were observed by HE staining. The relationship between HBVDNA content and liver pathology was analyzed. Results, the blood HBVDNA content and pathological changes in liver inflammation have a consistent relationship; the same time, duration of liver fibrosis and consistency. The results suggest that the content of HBVDNA in blood can reflect the extent of inflammation in liver tissue to a certain extent, anti-virus treatment to eliminate or reduce the content of HBVDNA is an indispensable treatment of HBV infection