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Myocardial infarction is a devastating disease worldwide.At present,nearly 40 million patients suffer from heart failure.Owing to a lack of adequate blood supply,25％of cardiomyocytes are sub-jected to apoptosis and necrosis within a few hours after infarction.It remains challenging to find effective therapeutic methods for heart failure.On the other hand,zebrafish and neonatal mouse hearts have a strong ability to regenerate(Poss et al.,2002;Raya et al.,2003;Porrello et al.,2011),and their regeneration derives from existing cardiomyocytes(Jopling et al.,2010;Kikuchi et al.,2010;Porrello et al.,2011).Over the past decade,a number of signaling pathways and transcription factors,such as fibroblast growth factor,neuregulin/Erbb2,Hippo/Yap,WNT,Notch,Brgl,and Meisl/HoxB13,are reported to be essential for myocardial pro-liferation and regeneration(Xiao et al.,2016;Tzahor and Poss,2017;Heallen et al.,2019;Nguyen et al.,2020;Sadek and Olson,2020).However,it remains unclear how myocardial proliferation and regeneration are achieved after cardiac iniury.