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目的 了解成都地区有无新型肝炎病毒 TTV感染和 TTV型肝炎。方法 采用 PCR法检测血清中 TTVDNA。对单纯 TTV感染病毒性肝炎进行临床分析。结果 在非—甲型肝炎患者中 2 9.78% (2 8/94) TTV DNA阳性 ,在甲—庚型肝炎中 30 % (12 /4 0 )阳性 ,在献血员中 2 0 % (6 /30 )阳性。单纯 TTV感染的肝炎患者平均年龄 41.7岁。肝功异常 TBx132 .6 5μmol/L ,AL T x5 16 .2 7U/L。临床表现 71.43% (2 0 /2 8)为急性肝炎 ,14.30 % (4 /2 8)为慢性肝炎 ,10 .7%(3/2 8)为重型肝炎 ,3.5 7% (1/2 8)为肝炎肝硬变。在合并感染中 83% (10 /12 )合并 HBV感染 ,8.3% (1/12 )合并 HCV感染 ,8.3(1/12 )合并 HBV、HCV形成三重感染。结论 成都地区存在 TTV感染和 TTV型肝炎 ,单纯 TTV感染以急性肝炎多见 ,TTV和 HBV易形成二重感染 ,且有慢性化和重型肝炎现象
Objective To know if there is a new type of hepatitis virus TTV infection and TTV hepatitis in Chengdu area. Methods The serum TTVDNA was detected by PCR. A simple TTV infection of viral hepatitis for clinical analysis. Results 2 9.78% (2 8/94) of TTV DNA were positive in non-hepatitis A patients, 30% (12/40) in A-HepG, 20% (6/30 in blood donors ) Positive. Patients with pure TTV infection had an average age of 41.7 years. Liver function abnormal TBx132 .6 5μmol / L, AL T x5 16.27U / L. The clinical manifestations were 71.43% (20/28) for acute hepatitis, 14.30% (4/8) for chronic hepatitis, 10.7% (3/2 8) for severe hepatitis and 3.57% (1/2 8) Hepatitis cirrhosis. HBV infection was found in 83% (10/12) of the co-infected patients, HCV infection in 8.3% (1/12) and HBV (HBV) 8.3 (1/12) in the triple infection. Conclusion There are TTV infection and TTV hepatitis in Chengdu area. TTV infection is more common in acute hepatitis, TTV and HBV are more likely to cause double infection, with chronic and severe hepatitis