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目的探讨在原发性高血压人群中微量白蛋白尿(MAU)的发生与心血管危险因素的相关性。方法从社区体检中心筛查出原发性高血压患者530例,收集研究对象的一般资料,并进行血生化指标及尿蛋白与肌酐比值的测定,根据检查结果分为MAU阳性组(n=141)及MAU阴性组(n=389)。结果 MAU阳性组年龄较大,男性及吸烟比例居多,收缩压、腰围、体质量指数、空腹血糖、糖化血红蛋白、尿酸、脉压差及平均动脉压明显高于MAU阴性组(均P<0.05);多元线性回归显示收缩压、糖化血红蛋白、总胆固醇及体质量指数是MAU发生的独立危险因素(P<0.05)。结论收缩压、糖化血红蛋白、总胆固醇及体质量指数是原发性高血压人群中MAU发生的独立危险因素。
Objective To investigate the relationship between microalbuminuria (MAU) and cardiovascular risk factors in essential hypertension. Methods A total of 530 patients with essential hypertension were screened from community health centers to collect general data of the study subjects. Blood biochemical parameters and urinary protein to creatinine ratio were determined. According to the results, the patients were divided into MAU positive group (n = 141 ) And MAU negative group (n = 389). Results The MAU positive group was older and had the highest prevalence of smoking. The systolic blood pressure, waist circumference, body mass index, fasting blood glucose, glycosylated hemoglobin, uric acid, pulse pressure and mean arterial pressure were significantly higher than those in the MAU negative group (all P <0.05) Multiple linear regression showed systolic blood pressure, glycosylated hemoglobin, total cholesterol and body mass index were independent risk factors of MAU (P <0.05). Conclusions Systolic blood pressure, glycosylated hemoglobin, total cholesterol and body mass index are independent risk factors for MAU in patients with essential hypertension.