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目的:探讨新生儿缺氧缺血性脑病(HIE)早期干预对其预后的影响。方法:选取HIE患儿80例,按照干预方法不同分为实验组和对照组,各40例。两组患儿均给予常规降压、吸氧及营养支持等治疗,实验组患儿在常规治疗基础上加用纳洛酮静脉滴注。结果:实验组患儿总有效率为85%,大大高于对照组(70%);实验组患儿在呼吸好转,意识恢复,惊厥消失及体征消失所用时间均短于对照组;干预治疗初期两组患儿评价分数比较差异无统计学意义(P>0.05),治疗结束后,实验组患儿评分明显高于对照组,差异均具有统计学意义(P<0.05)。结论:在HIE早期加用纳洛酮可以有效提高患儿预后疗效及降低死亡率,值得临床推广。
Objective: To investigate the effect of early intervention of neonatal hypoxic-ischemic encephalopathy (HIE) on its prognosis. Methods: Eighty children with HIE were selected and divided into experimental group and control group according to different intervention methods, 40 cases in each group. Two groups of children were given routine antihypertensive, oxygen and nutritional support and other treatment, experimental group on the basis of conventional treatment plus naloxone intravenous drip. Results: The total effective rate in the experimental group was 85%, which was significantly higher than that in the control group (70%). The experimental group had shorter breathing time, consciousness recovery, disappearance of convulsion and disappearance of signs. Compared with the control group, There was no significant difference between the two groups in evaluation scores (P> 0.05). After treatment, the score of children in experimental group was significantly higher than that in control group (P <0.05). Conclusion: The early use of naloxone in HIE can effectively improve the prognosis of children and reduce mortality, it is worth clinical promotion.