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术后盆腹腔粘连会导致无法估量的严重后果。动物实验和临床实践中曾试用各种抗粘连对策,但尚未发现可有效防止粘连形成或再形成的方法。 血管渗透因子(VPF)/血管内皮生长因子(VEGF)是各种正常和移行细胞分泌的二聚糖蛋白。血管内皮具有VPF特异性受体同形物,而且是VPF活动的主要靶部位。VPF的促进血管渗透性作用是组胺的1000倍以上。在上皮伤口愈合过程中,皮肤微血管内大分子物质渗出增多,这种高渗出与
Abdominal adhesions after surgery can lead to incalculable serious consequences. Animal experiments and clinical practice have tried a variety of anti-adhesion strategies, but no effective way to prevent the formation or re-formation of adhesion. Vascular Permeability Factor (VPF) / Vascular Endothelial Growth Factor (VEGF) is a dimeric glycoprotein secreted by a variety of normal and migratory cells. Vascular endothelium has a VPF-specific receptor isoform, and is the main target site for VPF activity. The effect of VPF on promoting vascular permeability is more than 1000 times that of histamine. In the process of epithelial wound healing, exudation of macromolecular substances in the skin capillaries is increased.