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目的探讨血清氨基末端脑钠肽(N-terminal pro-brain natriuretic peptide,NT-pro-BNP)和肌酸激酶同工酶MB(creatine kinase MB isoenzyme,CK-MB)在儿童肺炎合并心力衰竭诊断中的价值。方法选取儿童肺炎合并心衰、单纯肺炎和健康对照组各50例,采用化学发光法测定血清NT-pro-BNP和CK-MB值,统计分析3组的差异。并利用logistic回归模型分析血清NT-pro-BNP和CK-MB与心衰发生的关联。结果肺炎合并心衰组NT-pro-BNP,CK-MB值明显高于单纯肺炎组和健康对照组,差异有统计学意义(P<0.05)。单纯肺炎组与健康对照组相比,NT-pro-BNP值差异不具有统计学意义,但CK-MB值差异具有统计学意义。结论血清NT-pro-BNP和CK-MB是诊断儿童肺炎合并心衰的有效指标。
Objective To investigate the diagnostic value of serum N-terminal pro-brain natriuretic peptide (NT-pro-BNP) and creatine kinase MB isoenzyme (CK-MB) in the diagnosis of children with pneumonia complicated with heart failure the value of. Methods Fifty children with pneumonia complicated with heart failure, simple pneumonia and healthy control group were selected. The serum NT-pro-BNP and CK-MB values were determined by chemiluminescence method. The differences among the three groups were statistically analyzed. Logistic regression model was used to analyze the association of serum NT-pro-BNP and CK-MB with heart failure. Results NT-pro-BNP and CK-MB in patients with pneumonia complicated with heart failure were significantly higher than those in patients with pneumonia and healthy controls (P <0.05). Compared with healthy control group, the difference of NT-pro-BNP in simple pneumonia group was not statistically significant, but the difference of CK-MB value was statistically significant. Conclusion Serum NT-pro-BNP and CK-MB are effective indicators for the diagnosis of pneumonia complicated with heart failure in children.