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目的探讨C4·4A蛋白表达在鳞癌和腺癌诊断和鉴别诊断中的意义。方法应用免疫组织化学SP法检测并观察不同部位来源、不同分化程度的157例鳞状细胞癌和177例腺癌中C4·4A蛋白的表达。结果157例鳞状细胞癌中有141例C4·4A蛋白呈阳性表达,而177例腺癌中只有8例可检测C4·4A蛋白的部分或少量散在表达。鳞癌和腺癌C4·4A蛋白表达差异有统计学意义(χ2=244·93,P=0·000)。不同分化程度的鳞癌和腺癌两两比较,其C4·4A蛋白表达差异均有统计学意义(P=0·000)。结论C4·4A蛋白可作为区分鳞癌和腺癌的一个有价值的诊断标志物,有助于上皮性肿瘤的诊断及鉴别诊断。
Objective To investigate the significance of C4 · 4A protein expression in the diagnosis and differential diagnosis of squamous cell carcinoma and adenocarcinoma. Methods The expressions of C4 · 4A protein in 157 cases of squamous cell carcinoma and 177 cases of adenocarcinoma were detected by immunohistochemical SP method. Results There were 141 cases of C4 · 4A protein in 157 cases of squamous cell carcinoma, while only 8 cases of 177 cases of adenocarcinoma could detect C4 · 4A protein partially or sporadically. There were significant differences in the expression of C4 · 4A protein between squamous cell carcinoma and adenocarcinoma (χ2 = 244.93, P = 0.000). There were significant differences in C4 · 4A protein expression between squamous cell carcinoma and adenocarcinoma with different degree of differentiation (P = 0.000). Conclusions C4 · 4A protein can be used as a valuable diagnostic marker for differentiating squamous cell carcinoma from adenocarcinoma, which is helpful for the diagnosis and differential diagnosis of epithelial tumors.