Dear Editor,rnGhrelin, an endogenous ligand of growth hormone secretagogue receptor 1a (GHS-R1a), is a 28-amino-acid peptide that regulates growth hormone secretion, metabolism, food intake, mood, cognition, memory, and neuroprotection [1-3].Recent studies have suggested that these functions of ghrelin are achieved by its modulation of the electrophysiological properties of neurons.Andrews et al.showed that the excitatory effects of ghrelin on dopaminergic neurons in the substantia nigra pars compacta (SNc) are associated with neuroprotection and motor modulation [4, 5].Electrophysiologically, dopaminergic neurons are excitable cells with low-frequency pacemaker activity in vitro and tonic irregular single-spike or phasic bursting activity in vivo [5, 6].In addition, changes in neuronal activity affect dopamine release at the axon terminals, which in turn modulates basic motor activity [7].The ion channel mechanisms underlying the electrical activity ofthese cells are of particular interest and importance because of their relevance to voluntary movement and their involvement in neurological disorders such as Parkinson's disease (PD).