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目的探讨赣南地区药物性肝损害患者的临床表现特征和预后。方法回顾性分析2006年5月到2012年5月在赣南地区就诊的100例药物性肝损害患者的临床资料,总结一般资料、临床表现特征和预后。结果 100例患者中女71例,男39例,平均年龄(45.3±10.5)岁。导致肝损害的药物中以抗结核药为主(38.0%),其次为中药(21.0%)、减肥茶(14.0%)、抗微生物药(9.0%)等。临床类型中胆汁淤积型最多(50.0%)。临床主要表现包括疲乏(74%)、纳差(55%)、黄疸(54%)、恶心(46%)、呕吐(36%)、腹胀(25%)。临床治疗组治愈65例,好转24例,无效10例,死亡1例,总有效率为,89.0%,死亡率为1.0%。结论药物性肝损伤临床特点无特异性,可由多种药物引起,应早期诊断,停用致病药物,保肝治疗,预后较好。
Objective To investigate the clinical features and prognosis of drug-induced liver damage in southern Jiangxi Province. Methods The clinical data of 100 patients with drug-induced liver injury who were treated in Gannan from May 2006 to May 2012 were retrospectively analyzed. General information, clinical features and prognosis were summarized. Results Among 100 patients, 71 were female and 39 were male with an average age of (45.3 ± 10.5) years. Among the drugs that cause liver damage, anti-TB drugs are mainly 38.0%, followed by traditional Chinese medicine (21.0%), slimming tea (14.0%) and anti-microbial drugs (9.0%). Cholestasis type was the most common type of clinical (50.0%). Clinical manifestations include fatigue (74%), anorexia (55%), jaundice (54%), nausea (46%), vomiting (36%) and bloating (25%). In the clinical treatment group, 65 cases were cured, 24 cases improved, 10 cases were ineffective and 1 died. The total effective rate was 89.0% and the mortality rate was 1.0%. Conclusion The clinical features of drug-induced liver injury are nonspecific and can be caused by many drugs. Early diagnosis and stopping of pathogenic drugs should be stopped and liver protection treated. The prognosis is good.