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目的探讨影响食管癌切除术后患者的预后因素。方法对1992～2000年间接受手术治疗的971例食管癌术后患者预后进行研究。选择14个可能对食管癌切除术后预后产生影响的研究因素,通过Cox比例风险模型对术后患者预后进行多因素分析,并估计预后指数,以及用寿命表法计算累计生存率。结果全组3年生存率78.29%,5年生存率68.81%,中位生存期为97.49月。Cox多因素分析表明,影响预后的独立因素是临床分期、肿瘤部位、侵及深度、分化程度及淋巴结转移个数。结论全组患者3年、5年生存率较高,食管癌肿瘤临床分期是食管癌切除术后影响预后的重要因素。早期诊断病人,在临床分期的较早期实施手术,对患者预后及提高术后生存率具有非常重要意义。
Objective To investigate the prognostic factors in patients with esophageal cancer after resection. Methods The prognosis of 971 patients with esophageal cancer who underwent surgery between 1992 and 2000 was studied. Fourteen possible factors influencing prognosis after resection of esophageal cancer were selected. Multivariate analysis was performed on the prognosis of patients with esophageal cancer by Cox proportional hazard model. The prognostic index was estimated, and the cumulative survival rate was calculated by the life table method. Results The overall 3-year survival rate was 78.29%, the 5-year survival rate was 68.81%, and the median survival time was 97.49 months. Cox multivariate analysis showed that independent prognostic factors were clinical stage, tumor location, depth of invasion, degree of differentiation and lymph node metastasis. Conclusions The 3-year and 5-year survival rates of all patients are high. The clinical stage of esophageal cancer is an important factor affecting prognosis after esophageal cancer resection. Early diagnosis of patients in the clinical stage of the earlier implementation of surgery, the prognosis of patients and improve postoperative survival rate is of great significance.