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促红素(EPO)是由与近侧肾小管邻近并作为肾对氧敏感反应装置的细胞合成的一种糖蛋白的生长因子,可能是一种血红素蛋白。在骨髓中,EPO能结合到原始红细胞上并活化其上的特异性受体。由于这种EPO-受体复合物的存在,原始细胞继续它们预定的发展过程成为成熟的红细胞,如果无EPO-受体复合物,则原始细胞将崩溃及死亡。在正常稳定状态下,血浆中EPO浓度为10～20U/L(约2 pmol/L)即可诱导产生足量的红细胞以取代衰老的红细胞,并可保持到达肾氧感受器的足够氧流量,以保证基础水平EPO合成。在贫血时肾氧流量降低可指数性地增加EPO合成,因此在红细胞
Erythropoietin (EPO) is a glycoprotein’s growth factor, probably a heme protein, synthesized by cells that are proximal to the proximal tubules and act as a kidney-to-oxygen sensor. In the bone marrow, EPO binds to primitive erythrocytes and activates specific receptors thereon. Due to the presence of this EPO-receptor complex, the primordial cells continue their established development as mature erythrocytes, which, in the absence of the EPO-receptor complex, will collapse and die. Under normal steady state, plasma EPO concentration of 10-20 U / L (about 2 pmol / L) can induce a sufficient amount of erythrocytes to replace aged red blood cells and maintain adequate oxygen flow to the renal oxygen receptors to Ensure the basic level of EPO synthesis. Decreased renal oxygen flux during anemia can exponentially increase EPO synthesis and hence erythrocytes