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目的 研究E cadherin在甲状腺癌中的表达及其临床意义。方法 应用免疫组化方法 ,对19例甲状腺乳头状腺癌 ,12例甲状腺滤泡状腺癌和 17例甲状腺髓样癌进行了E cadherin表达的检测。结果 8例 ( 4 2 .1% )甲状腺乳头状腺癌E cadherin表达阳性 ,5例 ( 4 1.7% )甲状腺滤泡状腺癌E cad herin表达阳性 ,11例 ( 6 4.7% )甲状腺髓样癌E cadherin表达阳性。E cadherin表达在甲状腺癌各病理类型与甲状腺腺瘤之间比较 ,其阳性率差异有显著性 ;但在甲癌的三种病理类型之间其阳性率差异无显著性。E cadherin在甲状腺癌中的表达与年龄有相关性 ,但与其它各临床病理参数无明显的相关性。结论 在甲状腺癌中上皮细胞表面的E cadherin有一定的破坏或功能不正常 ,但尚不能成为甲状腺癌独立的预后指标。
Objective To study the expression of E cadherin in thyroid carcinoma and its clinical significance. Methods Immunohistochemistry was used to detect the expression of E cadherin in 19 cases of thyroid papillary adenocarcinoma, 12 cases of thyroid follicular adenocarcinoma and 17 cases of medullary thyroid carcinoma. Results E cadherin expression was positive in papillary thyroid carcinoma of thyroid in 8 cases (42.1%), E cadherin expression was positive in 5 cases (4.17%) of thyroid follicular adenocarcinoma, and in 11 cases (6 4.7%) of medullary thyroid carcinoma E cadherin expression was positive. The positive rate of E cadherin expression was significantly different between thyroid carcinoma and thyroid adenoma. However, the positive rate of E cadherin was not significantly different between the three pathological types of thyroid carcinoma. The expression of E cadherin in thyroid carcinoma was related to age, but not to other clinicopathological parameters. Conclusion E cadherin on the surface of epithelial cells in thyroid cancer has some damage or dysfunction, but it can not yet become an independent prognostic indicator of thyroid cancer.