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目的:探讨消化道肿瘤术后应用百普素行早期肠内营养支持的可行性、安全性和临床效果。方法:消化道肿瘤术后病人共42例,A组术后经空肠造口管用百普素行肠内营养支持,B组术后常规输液,肛门恢复排气后行一般流质饮食。临床观察胃肠道功能恢复情况以及各种不良反应,测定肠内营养支持前后病人的血清白蛋白、前白蛋白、血糖、肝肾功能、外周血淋巴细胞计数及累积氮平衡,记录各病人百普素的最大应用剂量及最大输注速度,以评价消化道肿瘤术后病人对百普素早期肠内营养应用的耐受性。结果:A组肛门排气恢复时间比B组早(P<0.05);A组1例应用百普素第3天并发休克、麻痹性肠梗阻;2例出现腹胀、腹痛,经调整速度和温度后缓解;1例为菌群失调及肠功能不全所致腹泻。所有病人无出现机械性肠梗阻、肠外瘘、腹壁软组织感染及高血糖等代谢并发症,肝肾功能正常。A组应用百普素后,前白蛋白比B组升高(P<0.05),A组术后淋巴细胞计数回升比B组高(P<0.05),血清白蛋白水平未见明显改变,累积氮平衡A组比B组高(P<0.05)。研究期间病人百普素的平均最大应用剂量(1386±225)mL(浓度4.2kJ/mL),最大输注速度(69±21)mL/h。结论:消化道肿瘤术后早期应用百普素行肠内营养治疗,能促进胃肠道功能恢复,改善营养状况及提高机体免疫功能;病人对百普素
Objective: To investigate the feasibility, safety and clinical effect of application of clenbuterol in early enteral nutrition after gastrointestinal cancer. Methods: A total of 42 patients underwent gastrointestinal cancer surgery. Group A received enteral nutrition support through the jejunostomy tube after operation. Group B received conventional fluid infusion and anus recovery after extubation. Clinical observation of gastrointestinal function recovery and various adverse reactions before and after enteral nutrition support determination of serum albumin, prealbumin, blood glucose, liver and kidney function, peripheral blood lymphocyte count and cumulative nitrogen balance, record each patient’s 100 The maximal applied dose and maximal infusion rate of Supranoside were evaluated to evaluate the tolerability of bergapten to enteral nutrition in patients with postoperative digestive tract tumors. Results: The recovery time of anus exhaust in group A was earlier than that in group B (P <0.05). In group A, clenbuterol and paralytic ileus were applied on the third day in group A, bloating and abdominal pain occurred in 2 cases, After remission; 1 case of flora and intestinal dysfunction caused by diarrhea. All patients without mechanical intestinal obstruction, intestinal fistula, abdominal soft tissue infections and hyperglycemia and other metabolic complications, liver and kidney function was normal. The prealbumin in group A was higher than that in group B (P <0.05), the number of lymphocyte in group A was higher than that in group B (P <0.05), but no significant change in serum albumin level Nitrogen balance was higher in group A than in group B (P <0.05). During the study period, the average maximum dose of berberine (1386 ± 225) mL (concentration 4.2kJ / mL) and maximum infusion rate (69 ± 21) mL / h were obtained. Conclusion: The application of clenbuterol enteral nutrition in early postoperative gastrointestinal cancer can promote gastrointestinal function recovery, improve nutritional status and improve immune function. Patients with berberine