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为了观察尿白蛋白及α_1-微球蛋白(α_1-M)对SLE早期肾损害的诊断价值,用放射免疫分析法测定了56例SLE患者尿白蛋白排泄率(UAER)和尿α_1-M,其中尿常规正常组30例,尿常规异常组26例。结果UAER和α_1-M在尿常规异常组(228.59±66.74mg/min和42.13±19.26mg/L)和尿常规正常组(23.05±21.85mg/min和20.17±16.64mg/L)均高于对照组(4.47±2.54mg/min和5.07±2.83mg/L),尿常规异常组又高于尿常规正常组,UAER与尿α_1-M呈显著正相关(r=0.74,P<0.01)。因此,24h尿白蛋白、α_1-M是诊断SLE早期肾损害的敏感指标。
In order to investigate the diagnostic value of urinary albumin and α 1-microglobulin (α 1-M) on early renal damage in SLE, the urinary albumin excretion rate (UAER) and urinary α 1-M were measured in 56 SLE patients by radioimmunoassay. Urine routine group of 30 cases, abnormal urine group of 26 cases. Results The levels of UAER and α_1-M were significantly higher in urine abnormal group (228.59 ± 66.74mg / min and 42.13 ± 19.26mg / L) and normal urine group (23.05 ± 21.85mg / min and 20.17 ± 16.64mg / L) (4.47 ± 2.54mg / min and 5.07 ± 2.83mg / L respectively). There was a significant positive correlation between UAER and urine α_1-M (r = 0.74, P <0.01) in urine abnormal group and normal urine group. Therefore, 24h urine albumin, α_1-M is a sensitive indicator of early diagnosis of SLE renal damage.