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目的观察鲑鱼降钙素(密钙息)、帕米膦酸盐联合化疗对多发性骨髓瘤骨痛的缓解度、起效时间及维持时间。方法42例多发性骨髓瘤伴骨痛患者随机分为两组,治疗组(25例)采用密钙息、帕米膦酸盐联合化疗;对照组(17例)采用帕米膦酸盐联合化疗。结果骨痛缓解总有效率治疗组为96.0%,对照组为88.2%,两组差异无统计学意义(P>0.05)。1周内起效的治疗组占76.0%,对照组占41.2%,两组差异有统计学意义(P<0.05)。骨痛缓解维持时间:可维持2周的比率治疗组为24.0%,对照组为47.1%;可维持4周的比率治疗组为64.0%,对照组为29.4%。治疗组骨痛缓解维持时间较对照组长(P<0.05)。结论在帕米膦酸盐联合化疗的同时,加用密钙息鼻喷剂治疗,虽疼痛缓解率无进一步提高,但骨痛缓解所需时间缩短,缓解持续时间延长。
Objective To observe the salvage of salmon calcitonin (calcium), pamidronate combined chemotherapy for multiple myeloma bone pain relief, onset time and maintenance time. Methods Forty-two patients with multiple myeloma with bone pain were randomly divided into two groups. The treatment group (25 cases) was treated with calcium-rich, pamidronate combined with chemotherapy. The control group (17 cases) received pamidronate combined with chemotherapy . Results The total effective rate of pain relief was 96.0% in the treatment group and 88.2% in the control group, with no significant difference between the two groups (P> 0.05). In the first week, 76.0% of the patients in the treatment group and 41.2% of the control group had significant difference (P <0.05). Maintenance of bone pain to maintain time: up to 2 weeks to maintain the treatment group was 24.0%, 47.1% in the control group; up to 4 weeks the ratio of treatment group was 64.0%, control group was 29.4%. In the treatment group, the pain relief time was longer than the control group (P <0.05). Conclusion Pamidronate combined with chemotherapy, plus the use of calcium calcium nasal spray treatment, although no further improvement in pain relief rate, but the time required for the relief of bone pain, reduce the duration of the delay.