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目的:探讨甲泼尼龙琥珀酸钠联合阿奇霉素治疗重症支原体肺炎患儿的效果及其对免疫功能的影响。方法:选取古交矿区总医院2015年12月至2017年10月收治的重症支原体肺炎患儿85例，按照随机数字表法分组，对照组42例采用阿奇霉素治疗，观察组43例采用阿奇霉素联合甲泼尼龙琥珀酸钠治疗，观察比较两组临床疗效、症状体征(发热、咳嗽、肺啰音)消失时间及治疗前后血清C反应蛋白(CRP)水平，并统计两组治疗前后血清免疫球蛋白M(IgM)、IgA、IgG水平变化。结果:观察组总有效率为93.02%(40/43)，高于对照组的76.19%(32/42)(χn 2＝4.647，n P＝0.031)；观察组发热、咳嗽、肺啰音消失时间均短于对照组(n t1＝4.787，n P1＝0.000，n t2＝5.746，n P2＝0.000，n t3＝6.418，n P3＝0.000)；观察组治疗后血清CRP水平低于对照组(n t＝16.797，n P＝0.000)；治疗后观察组血清IgM、IgA、IgG水平均高于对照组(n t1＝7.593，n P1＝0.000，n t2＝3.583，n P2＝0.001，n t3＝10.277，n P3＝0.000)。n 结论:甲泼尼龙琥珀酸联合阿奇霉素可减轻重症支原体肺炎患儿的炎性反应，调节其机体免疫功能，缩短症状体征消退时间。“,”Objective:To investigate the effect of methylprednisolone sodium succinate combined with azithromycin in the treatment of severe mycoplasma pneumonia.Methods:From December 2015 to October 2017, a total of 85 children with severe mycoplasma pneumonia in the General Hospital of Gujiao Mining Area were divided into two groups according to the random number table method, 42 cases in the control group were treated with azithromycin, and 43 cases in the observation group were treated with azithromycin+ methylprednisolone sodium succinate.The clinical efficacy, disappearing time of symptoms and signs(fever, cough, pulmonary rales) and the level of serum C reactive protein(CRP) were compared between the two groups.The changes of serum levels of immunoglobulin M(IgM), IgA and IgG in two groups before and after treatment were also statistically analyzed.Results:The total effective rate of the observation group was 93.02%(40/43), which was higher than that of the control group [76.19%(32/42)] (χn 2=4.647, n P=0.031). The disappearing time of fever, cough and pulmonary rales in the observation group were shorter than those in the control group(n t1=4.787, n P1=0.000, n t2=5.746, n P2=0.000, n t3=6.418, n P3=0.000). After treatment, the serum level of CRP in the observation group was lower than that in the control group(n t=16.797, n P=0.000). After treatment, the serum levels of IgM, IgA and IgG in the observation group were higher than those in the control group(n t1=7.593, n P1=0.000, n t2=3.583, n P2=0.001, n t3=10.277, n P3=0.000).n Conclusion:Methylprednisolone sodium succinate combined with azithromycin can reduce the inflammatory reaction of children with severe mycoplasma pneumoniae, regulate their immunity and promote the recovery of symptoms and signs.Besides, its efficacy is obvious.