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目的对中晚期帕金森病(PD)患者的生活质量进行评估并分析影响因素,为临床干预提供依据。方法选择符合PD诊断标准,并根据Hoehn&Yahr(H-Y)分级纳入中晚期患者83例,应用PD生命质量评价量表(PDQ-39)评定患者的总体生活质量,用SPSS22.0统计较软件对数据进行统计学分析。采用Spearman相关检验对PDQ-39与发病年龄、病程、左旋多巴等效剂量(LEDD)、Beck抑郁量表(BDI)的相关性进行分析;以PDQ-39总分为因变量,与BDI和LEDD为自变量进行多元逐步回归分析。结果相关性分析显示,中晚期PD患者的LEDD与PDQ-39总分呈弱相关(r=0.262,P=0.017),BDI与PDQ-39总分呈高相关性(r=0.687,P=0.000)。多元回归分析结果显示,中晚期PD患者的BDI、LEDD等2项变量对PDQ-39总分的影响占比为47.4%。结论抑郁及用药剂量对于中晚期PD患者生活质量有一定影响,对中晚期PD患者进行抗抑郁干预及左旋多巴类药物替代治疗,对改善患者生活质量有一定帮助。
Objective To evaluate the quality of life of patients with Parkinson’s disease (PD) in the late stage and analyze the influencing factors so as to provide the basis for clinical intervention. Methods According to PD diagnostic criteria, 83 patients with advanced stage were enrolled according to Hoehn & Yahr (HY) classification. The PDQ-39 was used to assess the overall quality of life of the patients. SPSS22.0 was used to compare the data with software Statistical analysis. The correlation between PDQ-39 and age, course of disease, equivalent dose of levodopa (LEDD) and Beck Depression Scale (BDI) were analyzed by Spearman’s correlation test. The PDQ-39 total score was used as the dependent variable, LEDD as independent variable multiple stepwise regression analysis. Results Correlation analysis showed that LEDD had a weak correlation with PDQ-39 score (r = 0.262, P = 0.017), PDI-39 and BDD showed a high correlation (r = 0.687, P = 0.000 ). Multiple regression analysis showed that the influence of two variables, BDI and LEDD, on PDQ-39 score was 47.4% in advanced PD patients. Conclusions Depression and medication dosage have certain influence on the quality of life of patients with advanced PD. Antidepressant intervention and replacement therapy of L-dopa drugs in patients with advanced PD may be helpful to improve the quality of life of patients.