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近年来,端粒、端粒酶成为肿瘤研究中的热点,对它们的研究有望对肾细胞癌(renal cell carcinoma, RCC)发生的分子生物学机制提供一个新的思路,并为RCC的诊断与治疗开辟一个新的途径。本文对RCC端粒、端粒酶的研究现状及其应用前景进行综述。 1 端粒(telomere)与RCC 1.1 端粒及其亚单位的结构与功能端粒是位于真核细胞线性染色体末端的特殊结构,是由端粒DNA和端粒结合蛋白构成的复合物。端粒为染色体末端提供了一个保护性
In recent years, telomere and telomerase have become the hot topics in tumor research, and their research is expected to provide a new idea for the molecular biological mechanism of renal cell carcinoma (RCC) Treatment opens up a new avenue. This review summarizes the research status of RCC telomeres and telomerase and its application prospect. Structure and function of telomere and RCC 1.1 telomere and its subunits Telomere is a special structure located at the end of linear chromosome of eukaryotic cells and is composed of telomere DNA and telomere binding protein. Telomere provides a protective end for the chromosome