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近几年来,醋酸棉酚的临床扩大试用进一步证实了棉酚是一种较好的抑精药物,但尚存一些副作用。为了降低毒性并提高药物抗生育效价而进行的剂型改革亦是一项重要工作,因此,我们特检查了几种棉酚衍化物的固相分散剂型的抑精作用,观察其是否能促进吸收,增强抑精效果。 利用健康成熟的雄性大鼠92只,分为10组,实验所用的醋酸棉酚及其固相分散剂、棉酚镁络合物及其固相分散剂,以及棉酚锰、棉酚硼、巴比妥棉
In recent years, clinical trials of gossypol acetate further confirmed that gossypol is a good antidepressant drug, but there are some side effects. In order to reduce the toxicity and improve the anti-fertility price of drugs, the reform of the dosage form is also an important task. Therefore, we specifically examined the anti-seduction effect of several solid-phase dispersions of gossypol derivatives to observe whether they can promote absorption. Enhance the effect of inhibiting sperm. 92 healthy male rats were used and divided into 10 groups. Gossypol acetate and its solid phase dispersant, gossypol magnesium complex and its solid phase dispersant, as well as gossypol manganese, gossypol boron, were used in the experiment. Barbital cotton