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血红素加氧酶是哺乳动物中血红素代谢的限速酶,它能分解血红素成胆绿素、一氧化碳和铁。其中血红素加氧酶-1又称诱导型血红素加氧酶,它在血管平滑肌细胞中表达,可以被诸多因素所诱导。由血红素加氧酶-1催化产生的一氧化碳是一种重要的内源性生物信使,目前研究已经表明了它在循环系统中的重要作用。血管平滑肌细胞的增殖和凋亡是众多的心血管疾病如高血压、动脉粥样硬化的病理基础。血红素加氧酶/一氧化碳系统与血管平滑肌细胞的增殖和凋亡有着密切的关系。目前研究发现不少心血管药物通过该系统影响平滑肌细胞的增殖和凋亡,为新药物的开发奠定了基础。
Heme oxygenase is the rate-limiting enzyme in the metabolism of heme in mammals. It breaks down heme to biliverdin, carbon monoxide and iron. Heme oxygenase-1, also known as inducible heme oxygenase, which is expressed in vascular smooth muscle cells, can be induced by many factors. Carbon monoxide, which is catalyzed by heme oxygenase-1, is an important endogenous bio-messenger. Current research has shown its important role in the circulatory system. Proliferation and apoptosis of vascular smooth muscle cells are the pathological basis of a large number of cardiovascular diseases such as hypertension and atherosclerosis. Heme oxygenase / carbon monoxide system and vascular smooth muscle cell proliferation and apoptosis are closely related. The current study found that many cardiovascular drugs through the system of smooth muscle cell proliferation and apoptosis, laid the foundation for the development of new drugs.