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用单克隆抗体固相酶免疫法检测９０例各病期肾脏疾病患者血清Ⅳ型胶原（ＣＬ－ＩＶ）水平，并结合患者肾组织病理改变进行初步探讨。发现血清ＣＬ－ＩＶ在肾病患者中均有不同程度增高，并与疾病严重程度关系密切。提示ＣＬ－ＩＶ可能参与肾小球疾病发展和硬化过程。对它进行检测，似可作为临床监测肾病患者病情活动及进展的一项简便的辅助指标。
Serum level of type Ⅳ collagen (CL-IV) in 90 patients with renal disease at various stages of disease was detected by enzyme-linked immunosorbent assay (ELISA). The pathological changes of renal tissue were also discussed. Serum CL-IV were found in patients with nephropathy were increased to varying degrees, and closely related to the severity of the disease. Suggesting that CL-IV may be involved in glomerular disease development and hardening process. It can be used as a clinical monitoring of patients with renal disease activity and progress of a simple auxiliary indicators.