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目的观察周剂量多西紫杉醇联合顺铂及与5-氟尿嘧啶(5-Fu)治疗晚期胃癌的疗效和毒副反应。方法28例晚期胃癌患者,Karnofsky评分≥70分,预计生存期>3个月,未接受手术且未行任何化疗。多西紫杉醇25mg/m2静脉滴注,顺铂30mg/m2静脉滴注,5-Fu600mg/m2(24h持续泵入),均为第1、8、15天使用。行2周治疗后判定疗效并随访。结果28例患者均完成2个周期以上化疗,其中CR1例,PR11例,SD10例,PD6例,有效率42.9%。毒副反应主要表现为骨髓抑制、脱发和消化道反应,其他毒副反应较少,且可耐受,无化疗相关死亡。结论周剂量多西紫杉醇联合顺铂及5-Fu作为晚期胃癌的一线化疗方案,具有疗效相对较高,不良反应相对较小的优点。
Objective To observe the efficacy and side effects of weekly doses of docetaxel combined with cisplatin and 5-fluorouracil (5-Fu) in the treatment of advanced gastric cancer. Methods 28 patients with advanced gastric cancer, Karnofsky score ≥ 70 points, the expected survival of> 3 months, no surgery and no chemotherapy. Docetaxel 25mg / m2 intravenous infusion of cisplatin 30mg / m2 intravenous infusion of 5-Fu600mg / m2 (24h continuous pump), are the first 1,8,15 days use. After 2 weeks of treatment to determine the efficacy and follow-up. Results 28 patients completed more than two cycles of chemotherapy, CR1 cases, PR11 cases, SD10 cases, PD6 cases, the effective rate of 42.9%. Toxicity mainly manifested as myelosuppression, hair loss and gastrointestinal reactions, other less toxic side effects, and can be tolerated, no chemotherapy-related deaths. Conclusion Week dose of docetaxel combined with cisplatin and 5-Fu as a first-line chemotherapy for advanced gastric cancer, with relatively high efficacy, the advantages of relatively small adverse reactions.