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系膜增殖性肾炎是临床最常见的肾炎类型，为探讨中药治疗系膜增殖性肾炎的作用机理，笔者采用Ｗｉｓｔａｒ大鼠制作系膜增殖性肾炎动物模型，并观察了肾清冲剂对实验大鼠的治疗作用，实验结果表明：肾清冲剂可明显降低实验大鼠的尿蛋白，阻止肾脏病理改变的进展，保护肾单位；肾脏组织学及免疫荧光检查显示，肾清冲剂具有促进肾小球病理改变恢复的作用，同时，可以减少肾小球系膜区免疫复合物的沉积，其机理可能与通过调节机体的体液免疫和细胞免疫功能，减少循环免疫复合物的形成，或增强免疫系统的吞噬作用有关。
Mesangial proliferative nephritis is the most common type of nephritis in the clinic. In order to explore the mechanism of traditional Chinese medicine in the treatment of mesangial proliferative nephritis, the authors used Wistar rats to make an animal model of mesangial proliferative nephritis, and observed the effect of nephrin granules on experimental rats. The experimental results showed that: Shenqing Granules can significantly reduce the urinary protein of experimental rats, prevent the progression of renal pathological changes, and protect the nephron. Renal histology and immunofluorescence examination showed that Shenqing Granules promote glomerular pathology. Altering the effect of recovery, at the same time, it can reduce the deposition of immune complexes in the glomerular mesangium. The mechanism may be through regulating the body’s humoral and cellular immune functions, reducing the formation of circulating immune complexes, or enhancing the immune system’s phagocytosis. Role related.