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目的:采用MSCT灌注成像技术研究肝硬化患者肺部微循环灌注参数的变化。材料和方法:对20例正常对照组、24例代偿期肝硬化组和19例失代偿期肝硬化组行16层螺旋CT肺部同层动态增强扫描后,在工作站上使用perfusion3软件包对扫描数据进行处理,得出感兴趣区的时间-密度曲线(time-density curve,TDC)和各灌注参数值,包括血流量(blood flow,BF)、血容量(blood volume,BV)、对比剂平均通过时间(mean transit time,MTT)和表面渗透积乘积(permeability surface area product,PS)。采用SPSS11.5软件包对上述数据进行统计学分析。结果:BF、BV值在各组的总体均数差别有统计学意义(P<0.01)。失代偿期肝硬化组的BF、BV值较正常对照组和代偿期肝硬化组都明显增加,组间差别有统计学意义(P<0.01)。代偿期肝硬化组的BF、BV值与正常对照组比较,组间差别无统计学意义(P>0.05)。MTT值各组的总体均数间差别有统计学意义(0.05>P>0.01)。失代偿期肝硬化组的MTT值较正常对照组和代偿期肝硬化组减少,组间差别有统计学意义(0.05>P>0.01)。PS值各组间差别无统计学意义(P>0.05)。结论:MSCT肺部微循环灌注成像技术可反映肝硬化患者病情程度。
Objective: To study the changes of pulmonary microcirculation perfusion parameters in patients with liver cirrhosis by MSCT perfusion imaging. MATERIALS AND METHODS: Twenty-four normal spiral CT spiral scans of 20 normal controls, 24 compensated cirrhotic patients and 19 decompensated cirrhotic patients were performed on the same workstation with perfusion3 software package The scanned data were processed to obtain the time-density curve (TDC) of the region of interest and the perfusion parameter values, including blood flow (BF), blood volume (BV) Mean transit time (MTT) and permeability surface area product (PS) were used. SPSS11.5 software package for statistical analysis of the above data. Results: There was a significant difference in the mean of BF and BV between groups (P <0.01). The values of BF and BV in decompensated cirrhosis group were significantly higher than those in normal control group and compensated cirrhosis group, with significant difference between the two groups (P <0.01). BF and BV in decompensated cirrhosis group were not significantly different from those in normal control group (P> 0.05). There was a significant difference in the overall mean of MTT between groups (0.05> P> 0.01). The MTT value of decompensated cirrhosis group was lower than that of normal control group and compensated cirrhosis group, the difference was statistically significant (0.05> P> 0.01). There was no significant difference in PS between the groups (P> 0.05). Conclusion: MSCT lung microcirculation perfusion imaging can reflect the severity of patients with cirrhosis.