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目的探讨以羟喜树碱为主的化疗药物行肝动脉栓塞治疗原发性肝癌的临床疗效。方法 82例原发性肝癌患者 ,随机分为常规药物组 (A组 )和羟喜树碱为主化疗药物组 (B组 ) ,两组均给予经皮肝动脉插管化疗栓塞治疗 ,至少两疗程 ,疗效及毒性判定按照 WHO标准。结果 A组完全缓解 (CR) 19.5 1% ,部分缓解 (PR) 2 1.95 % ,总有效率 (CR+ PR) 41.46% ;B组 CR 2 1.95 % ,PR 3 6.5 9% ,CR+PR 5 8.5 4% ,两组之间有显著性差异。但不良反应两组之间无显著性差异。结论以羟喜树碱为主的化疗药物栓塞治疗原发性肝癌有显著疗效。
Objective To investigate the clinical efficacy of hydroxycamptothecin-based chemotherapy in the treatment of primary liver cancer with hepatic artery embolization. Methods 82 patients with primary liver cancer were randomly divided into conventional drug group (A group) and hydroxycamptothecin-based chemotherapy group (B group), and both groups were given transcatheter arterial chemoembolization, at least two Course of treatment, efficacy and toxicity in accordance with WHO standards. Results The complete remission (CR) 19.5 1%, partial remission (PR) 2 1.95%, total effective rate (CR + PR) 41.46% in group A, CR 2 1.95%, PR 3 6.5 9%, CR + PR 5 8.5 4 %, There are significant differences between the two groups. However, there was no significant difference between the two groups. Conclusion Hydroxycamptothecine based chemoembolization has a significant effect on primary liver cancer.