宫颈癌是女性最常见的恶性肿瘤之一,其发病率仅次于乳腺癌,并呈逐渐年轻化的趋势[1]。宫颈癌的发病原因有多个方面,自1978年德国病毒学家Harald zur Hausen首先提出人乳头瘤病毒(HPV)是宫颈癌的重要致病因素的假说后,一系列的后续研究证实,约98.5%的侵袭性宫颈癌中可检测到HPV,因此,宫颈癌的发生发展与HPV病毒的感染有着密切关系。宫颈癌的发生是一个由癌前病变逐步演变为癌的连续的病理过程。宫颈上皮内瘤变(CIN)为宫颈癌的 Cervical cancer is one of the most common malignant tumors in women, its incidence is second only to that of breast cancer, and shows a trend of becoming younger [1]. Cervical cancer has many causes, since the German virologist Harald zur Hausen first proposed in 1978 the hypothesis that human papillomavirus (HPV) is an important causative agent of cervical cancer, a series of follow-up studies confirmed that about 98.5 % Of invasive cervical cancer can be detected in HPV, therefore, the occurrence and development of cervical cancer and HPV virus infection are closely related. The occurrence of cervical cancer is a continuous pathological process that gradually evolves from precancerous lesions to cancers. Cervical intraepithelial neoplasia (CIN) for cervical cancer