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目的回顾性分析医院急诊使用4种非甾体抗炎药对输尿管结石所致肾绞痛的临床疗效,探寻治疗肾绞痛最佳方案。方法根据使用的4种非甾体抗炎药,将247例肾绞痛患者患者分为4组。1组107例;2组42例;3组46例;4组52例。1组:赖氨匹林注射液0.9g静脉滴注;2组:吲哚美辛栓0.5g纳肛;3组:布洛芬混悬剂0.3g口服;4组:双氯芬酸钠注射液50mg肌内注射。评价治疗效果并进行分析。结果 1组总有效率高于其他3组(P<0.05);3、4组总有效率高于2组(P<0.05)。1、3、4组不良反应发生率均低于2组,差异有统计学意义(P<0.05)。治疗后1组疼痛分数低于2、3、4组(P<0.05);各组治疗后疼痛分数均低于治疗前(P<0.05)。1组起效时间短于其他3组(P<0.05);3、4组起效时间短于2组,差异均有统计学意义(P<0.05)。结论赖氨匹林在显效率、止痛程度,起效时间上优于其他3种药物。静脉注射赖氨匹林是治疗输尿管结石所致肾绞痛的最佳选择。
Objective To retrospectively analyze the clinical efficacy of four kinds of nonsteroidal anti-inflammatory drugs in hospital emergency treatment of renal colic caused by ureteral stones, to explore the best treatment of renal colic. Methods According to the 4 NSAIDs used, 247 patients with renal colic were divided into 4 groups. 1 group of 107 cases; 2 group of 42 cases; 3 groups of 46 cases; 4 groups of 52 cases. Group 1: L-amiloxamine injection 0.9g intravenous infusion; Group 2: indometacin suppository 0.5g anal; Group 3: ibuprofen 0.3g oral suspension; 4 groups: diclofenac sodium injection 50mg muscle Internal injection. Evaluation of treatment and analysis. Results The total effective rate of group 1 was higher than that of the other 3 groups (P <0.05). The total effective rate of group 3 and 4 was higher than that of group 2 (P <0.05). 1,3,4 groups of adverse reactions were lower than the incidence of two groups, the difference was statistically significant (P <0.05). After treatment, the scores of pain in group 1 were lower than those in groups 2, 3 and 4 (P <0.05). The scores of pain after treatment in each group were lower than those before treatment (P <0.05). The onset time of group 1 was shorter than that of the other three groups (P <0.05). The onset time of group 3 and 4 was shorter than that of group 2 (P <0.05). Conclusion: L-aspirin is superior to the other three drugs in terms of markedly effective rate, analgesic effect and onset time. Intravenous aspirin is the best treatment for renal colic caused by ureteral stones.