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目的观察曲美他嗪对急性冠脉综合征心功能不全的治疗结果。方法选择急性冠脉综合征心功能Ⅲ、Ⅳ级患者316例,随机分为对照组158例,治疗组158例,对照组用常规疗法,治疗组在常规治疗基础上加用曲美他嗪(20 mg/次,3次/d口服),在治疗前和治疗后半年评价曲美他嗪对心功能的影响。结果治疗前和治疗后0.5 a心功能改善总有效率98%,无效率2%,P<0.05;两组治疗后6 min步行距离,与治疗前比较P<0.01及P<0.05;治疗组与对照组比较,P<0.05。结论常规治疗基础上加用曲美他嗪6个月,可使急性冠脉综合征患者心功能明显改善,延缓心室重构,曲美他嗪可作为治疗急性冠脉综合征心功能不全的辅助用药。
Objective To observe the therapeutic effect of trimetazidine on cardiac insufficiency in patients with acute coronary syndrome. Methods 316 patients with grade Ⅲ and Ⅳ of acute coronary syndrome were randomly divided into control group (158 cases) and treatment group (158 cases). The control group was treated with conventional therapy. The treatment group was treated with trimetazidine 20 mg / time, 3 times / d orally), the influence of trimetazidine on cardiac function was evaluated before treatment and six months after treatment. Results The improvement of cardiac function before treatment and 0.5 second after treatment was 98% and 2% respectively, P <0.05; the walking distance was 6 min after treatment, P <0.01 and P <0.05 before treatment; Control group, P <0.05. Conclusion Trimetazidine combined with trimetazidine for 6 months on conventional therapy can significantly improve cardiac function and delay ventricular remodeling in patients with acute coronary syndromes. Trimetazidine can be used as an auxiliary to treat cardiac insufficiency in patients with acute coronary syndrome Medication.