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肝细胞癌(HCC)是一种由肝细胞增生和凋亡比例失调而致的多因素、多阶段的恶性肿瘤。肝细胞在细菌脂多糖或γ-IFN刺激下可分泌IP-10、Mig等趋化因子,其本身也可表达CXCR3。CXCR3是一种7次跨膜G蛋白耦联受体,3个N-糖基化位点分别结合IP-10、Mig及I-TAC,介导炎症反应及血管生成等。在很多肿瘤中均可见CXCR3异常表达,在肝细胞癌发生发展中,CXCR3对机体的免疫调节及肿瘤血管生成起重要作用。
Hepatocellular carcinoma (HCC) is a multi-factor, multi-stage malignancy caused by an imbalance of hepatocyte proliferation and apoptosis. Liver cells can secrete chemokines such as IP-10, Mig and the like under the stimulation of bacterial lipopolysaccharide or γ-IFN, which themselves can express CXCR3. CXCR3 is a seven-transmembrane G protein-coupled receptor. Three N-glycosylation sites bind to IP-10, Mig and I-TAC, respectively, mediating inflammatory responses and angiogenesis. CXCR3 is abnormally expressed in many tumors. In the development of hepatocellular carcinoma, CXCR3 plays an important role in the immune regulation and tumor angiogenesis.