脑钠素(BNP)是近年来人们首先从猪脑提取物中分离出的一种和心钠素(ANP)性质不同的26氨基酸多肽。猪BNP和ANP的氨基酸序列分析表明,BNP缺乏ANP氨基端的3个氨基酸残基,而在羧基端则具有另外一个精氨酸残基。两者在结构上虽有这些差异,但都具有舒张平滑肌和诱发利钠、利尿的效应。BNP和ANP共有的生物活性提示两者可能作用于相同的受体。本文作者通过研究的①ANP和BNP结合位点在大鼠肾脏和心脏 Brain natriuretic peptide (BNP) is a 26 amino acid peptide that is different from atrial natriuretic peptide (ANP) in human porcine brain isolated in recent years. Amino acid sequence analysis of porcine BNP and ANP indicated that BNP lacks 3 amino acid residues at the amino terminus of ANP and another arginine residue at the carboxy terminus. Although both of these differences in the structure, but they have diastolic smooth muscle and induce sodium, diuretic effect. The biological activity shared by both BNP and ANP suggests that both may act on the same receptor. The authors studied ① ANP and BNP binding sites in rat kidney and heart