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本文采用人外周血淋巴细胞程序外DNA合成(UDS)方法检测对—氨基苯甲酸(PABA)、亚硫酸氢钠(NaHSO_3)对甲基硝基亚硝基胍的抗诱变作用,结果表明不同浓度的PABA,NaHSO_3对相同浓度的甲基硝基亚硝基胍(MNNG)的抗诱变作用,以PABA浓度为5×10~(-5)mol/L,NaHSO_3浓度为3×10~(-4)mol/L时,抗诱变作用最大。而PABA、NaHSO_3浓度恒定时,对不同浓度的MNNG的抗诱变作用,均以高浓度MNNG的抗诱变作用明显。因此认为PABA、NaHSO_3对MNNG具有抗诱变作用,其大小与MNNG的浓度有关。
In this study, the anti-mutagenic effects of p-aminobenzoic acid (PABA) and sodium bisulfite (NaHSO_3) against N-nitrosoguanidine were detected by the method of peripheral blood lymphocyte extracellular DNA synthesis (UDS) Concentration of PABA, NaHSO_3 on the same concentration of nitrosoguanidine (MNNG) anti-mutagenic effect to PABA concentration of 5 × 10 ~ (-5) mol / L, NaHSO_3 concentration of 3 × 10 ~ ( -4) mol / L, the anti-mutagenic effect is the largest. However, when the concentration of PABA and NaHSO_3 was constant, the anti-mutagenic effects of MNNG at different concentrations were all markedly inhibited by high concentration of MNNG. Therefore, PABA, NaHSO_3 on MNNG anti-mutagenic effect, its size and the concentration of MNNG.