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本文以３３名１８～３３岁青年人（无龋组、冠龋组）和５２名４７～７４岁中、老年人（无龋组、冠龋组、根龋组）为检测对象，对唾液内主要致龋菌（变链菌、放线菌、乳杆菌）及免疫活性物质（ＳＩｇＡ、ＩｇＧ、ＩｇＡ、ＩｇＭ、Ｃ３和Ｃ４）进行了测定。结果表明，龋患者唾液内变链菌（ＭＳ、２０％蔗糖）计数显著高于无龋者，而放线菌（ＣＦＡＴ）、乳杆菌（Ｒｏｇｏｓａ）在两者之间无显著差异。龋患者唾液ＳＩｇＡ高于无龋者，且在青年人中存在显著差异。中老年龋患者ＩｇＧ和ＩｇＭ显著增高，可能与代偿平衡有关。
In this study, 33 young people aged from 18 to 33 (caries-free group, carious crown caries group) and 52 middle-aged and elderly people aged 47 to 74 (caries-free group, carious caries group and root caries group) The main cariogenic bacteria (Streptococcus mutans, actinomycetes, Lactobacillus) and immunocompetent substances (SIgA, IgG, IgA, IgM, C3 and C4) were measured. The results showed that the count of Saliva Streptococcus mutans (MS, 20% sucrose) in caries was significantly higher than those in caries-free, while there was no significant difference between actinomyces (CFAT) and lactobacilli (Rogosa). Salivary SIgA was higher in caries than in caries-free subjects and was significantly different among young adults. IgG and IgM were significantly higher in middle-aged and elderly caries patients, which may be related to compensatory balance.