慢性粒细胞白血病(CML)是一种起源于多能干细胞恶性转化的骨髓增生性疾病,临床上以骨髓和外周血中出现过多的粒细胞及其前体细胞为特征。迄今引起CML的特殊病因尚未明瞭。细胞遗传学研究表明:大约90％以上的CML患者其白血病细胞中可发现Ph染色体,其通常由9号和22号染色体相互易位[t(9;22)(q 34 1;q11 21)]形成。近几年对CML的基因重排及其与临床之间的关系进行了深入研究,取得了长足进展。 Chronic myelogenous leukemia (CML) is a myeloproliferative disease that originates from the malignant transformation of pluripotent stem cells and is characterized clinically by the presence of excessive granulocytes and their precursors in bone marrow and peripheral blood. The specific etiology of CML so far remains unclear. Cytogenetics studies have shown that Ph chromosome can be found in leukemia cells in more than 90% of CML patients, which usually translocates from chromosomes 9 and 22 [t (9; 22) (q 34 1; q11 21)] form. In recent years, CML gene rearrangement and its relationship with the clinical conducted in-depth study and made considerable progress.