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目的探讨与分析老年妇女骨密度和髋部骨折的相关性。方法选择2011年8月~2015年2月在深圳福田医院诊治的老年妇女髋部骨折患者72例作为骨折组,选择同期在该院进行体检的72例健康老年妇女作为对照组,两组均进行骨密度与骨代谢生化指标检测,同时进行骨质疏松情况的判断与相关性分析。结果骨折组与对照组沃氏三角区的骨密度分别为(0.76±0.12)g/cm2和(0.83±0.46)g/cm2,骨折组明显低于对照组(t=9.134,P=0.000)。骨折组的血清抗酒石酸酸性磷酸酶值比对照组低,骨钙素值比对照组高,其差异具有统计学意义(P<0.05)。骨折组的骨质疏松与骨量减少发生率都明显高于对照组(P<0.05)。Pearson相关分析显示髋部骨折的发生与骨质疏松情况、骨钙素含量呈现明显正相关性(r=0.344,r=0.225,P<0.05),而与骨密度、抗酒石酸酸性磷酸酶含量呈现明显负相关性(r=-0.246,r=-0.341,P<0.05)。结论老年妇女髋部骨折多伴随有骨密度下降与骨质疏松情况,同时骨代谢生化指标表达紊乱,髋部骨密度可作为预测和评价老年妇女髋部骨折的主要检测指标。
Objective To investigate and analyze the correlation between bone mineral density and hip fracture in elderly women. Methods Seventy-two elderly patients with hip fracture who were diagnosed and treated in Shenzhen Futian Hospital from August 2011 to February 2015 were selected as the fracture group and 72 healthy elderly women who underwent physical examinations in the same period were selected as the control group. Bone mineral density and biochemical markers of bone metabolism, at the same time to determine the situation and the correlation analysis of osteoporosis. Results The BMD of the Wrigley’s triangle between the fracture group and the control group were (0.76 ± 0.12) g / cm2 and (0.83 ± 0.46) g / cm2, respectively, significantly lower than those in the control group (t = 9.134, P = 0.000). The serum tartrate-resistant acid phosphatase in the fracture group was lower than that in the control group, and the osteocalcin value was higher in the fracture group than in the control group. The difference was statistically significant (P <0.05). The incidence of osteoporosis and osteopenia in fracture group were significantly higher than that in control group (P <0.05). Pearson correlation analysis showed that the occurrence of hip fracture was positively correlated with osteoporosis and osteocalcin (r = 0.344, r = 0.225, P <0.05), but not with tartrate and tartrate-resistant acid phosphatase Significant negative correlation (r = -0.246, r = -0.341, P <0.05). CONCLUSIONS: Hip fractures in elderly women are often accompanied by decreased bone mineral density and osteoporosis. In addition, biochemical markers of bone metabolism are disturbed. Hip bone mineral density can be used as a predictor of the hip fracture in elderly women.