论文部分内容阅读
目的总结分析皮下脂膜炎样T细胞淋巴瘤的基因诊断以及病理特点,从而为皮下脂膜炎样T细胞淋巴瘤的诊断提供重要依据。方法以该院2014年1月—2017年3月期间接收的12例皮下脂膜炎样T细胞淋巴瘤患者作为研究对象,回顾分析所有患者的病理特点以及基因诊断情况等。结果在临床病理特点方面,2例患者出现皮肤溃疡,10例患者伴有不同程度的发热,所有患者均有相关部位皮下硬结或者是结节红斑表现。在镜下可见脂肪细胞周边有大小不等的非典型肿瘤细胞在生长,通过免疫学检查后,免疫组化特征表现为CD3十(100.0%)、CD4±(100.0%)、CD8+(100.0%)、CD20-(100.0%)、TI1-1(100.0%)、TCRβF-1+(100.0%)、CD56-(83.0%)、TIA-1+(100.0%)、穿孔素阳性(100.0%)。结论根据皮下脂膜炎样T细胞淋巴瘤的临床病理特点以及基因诊断后对应的免疫组化特征,可为该病的诊断提供重要依据,便于及时对患者进行治疗。
Objective To summarize and analyze the gene diagnosis and pathological features of subcutaneous panniculitis-like T-cell lymphoma, and to provide an important basis for the diagnosis of subcutaneous panniculitis-like T-cell lymphoma. Methods A total of 12 patients with subcutaneous panniculitis-like T-cell lymphoma received from January 2014 to March 2017 in our hospital were retrospectively analyzed for the pathological features and gene diagnosis of all patients. Results In terms of clinicopathological features, skin ulcers were found in 2 patients and fever in varying degrees in 10 patients. All patients had subcutaneous induration or erythema nodosum findings. In the microscope, atypical tumor cells of varying sizes around the fat cells were observed to grow. Immunohistochemical results showed that CD3 (100.0%), CD4 (100.0%), CD8 + (100.0% , CD20- (100.0%), TI1-1 (100.0%), TCRβ F-1 + (100.0%), CD56- (83.0%), TIA-1 + (100.0%), and perforin positive (100.0%). Conclusion According to the clinicopathological characteristics of subcutaneous panniculitis-like T-cell lymphoma and the corresponding immunohistochemical characteristics after gene diagnosis, it can provide an important basis for the diagnosis of the disease and facilitate the timely treatment of the patients.