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目的:总结妊娠期急性脂肪肝(AFLP)患者的诊治办法。方法:回顾性分析我院收治的10例AFLP患者的临床诊治资料。结果:70%患者以消化道症状为首发症状,20%因产检提示肝功能异常入院,经检查,所有患者均伴有不同程度实验室与相关辅助检查异常情况;所有患者均在入院1d内尽早做出临床诊断,并给予综合治疗与终止妊娠处理,10例孕妇均好转出院,1例死胎,3例后出血情况,1例肾功能衰竭,1例胎盘早剥,经抢救后全部生存。1例死胎,2例新生儿窒息。结论:尽早确诊、及时终止妊娠、综合治疗是有效改善AFLP患者与新生儿预后的重点所在。
Objective: To summarize the diagnosis and treatment of acute fatty liver of pregnancy (AFLP). Methods: The clinical data of 10 AFLP patients admitted to our hospital were retrospectively analyzed. Results: 70% of patients with gastrointestinal symptoms as the first symptom, 20% due to check-up prompted liver dysfunction admitted to the hospital, after examination, all patients were associated with varying degrees of laboratory and related ancillary examination of an anomaly; all patients as soon as possible within 1d admission 10 cases of pregnant women were discharged, 1 case of stillbirth, 3 cases of post-operative bleeding, 1 case of renal failure, 1 case of placental abruption, all survived after rescue. 1 stillbirth, 2 neonatal asphyxia. Conclusion: Early diagnosis and timely termination of pregnancy, comprehensive treatment is effective in improving the prognosis of AFLP patients and neonates.