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视黄酸(retinA或tretinoin,又译全反视黄酸)是视黄醛即维生素A的初级代谢产物。皮肤病学家在50多年前就已知维生素A有滋润皮肤的作用。早在1932年就已用实验证明,口服大量的维生素A对治疗牛皮癣有效。但有效口服量太大,以致使病人产生副作用,即维生素A过多症,例如皮肤脱皮、瘙痒、脱发、头痛、头晕。由于副作用太大,迫使皮肤病学家放弃了利用维生素A治疗牛皮癣的做法。
Retinoic acid (retinA or tretinoin, also translated total trans retinoic acid) is the primary metabolite of retinal that vitamin A. Dermatologists know that vitamin A has a moisturizing effect on the skin more than 50 years ago. As early as 1932, experiments have proved that oral administration of large amounts of vitamin A is effective in treating psoriasis. But the effective oral dose is too large, so that patients have side effects, that is, vitamin A hyperactivity, such as skin peeling, itching, hair loss, headache, dizziness. Because of the side effects, forcing dermatologists to give up the use of vitamin A in the treatment of psoriasis.