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十字花科蔬菜中的异硫氢酸盐成分对癌症具有重要的化学预防作用[1,2],莱菔子素(sulforaphane,SFN)为异硫代氰酸盐衍生物,可诱导机体产生Ⅱ型解毒酶,增加对致癌物的代谢解毒作用。我们在SFN诱导结肠癌细胞株Caco2葡萄糖醛酸转移酶1A(UGT1A)表达的研究中发现,这种植物化学保护剂
Isothiocyanate in cruciferous vegetables has an important chemopreventive effect on cancer [1,2]. Sulforaphane (SFN) is an isothiocyanate derivative that induces the production of type II Detoxification enzymes, increase the role of carcinogens metabolic detoxification. In a study of the SFN-induced colon carcinoma cell line Caco2 glucuronosyltransferase 1A (UGT1A) expression, we found that this phytochemical protectant