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心力衰竭是一种复杂的临床症状群,是各种心脏病的严重阶段,其发病率高,5年存活率与恶性肿瘤相仿。慢性心力衰竭时心肌细胞凋亡及其在心力衰竭病程发展中的机制成为当前的一个研究热点。现就Bcl-2和caspase在慢性心力衰竭中表达的调节因素的研究进展作一综述。
Heart failure is a complex group of clinical symptoms, is a serious stage of various heart disease, its incidence is high, 5-year survival rate and malignant tumors are similar. Apoptosis of cardiomyocytes in chronic heart failure and its mechanism in the pathogenesis of heart failure become a hot research topic. The research progress on the regulatory factors of Bcl-2 and caspase expression in chronic heart failure is reviewed.