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目的：探讨应用0．5％聚维酮碘冲洗结膜囊预防白内障术后眼内炎的效果。方法将2012年10月至2013年10月手术治疗的4000例老年性白内障患者随机分为两组，实验组术前应用0．5％聚维酮碘冲洗结膜囊，3 min后用无菌生理盐水冲洗结膜囊；对照组应用妥布霉素、无菌生理盐水冲洗结膜囊。观察两组冲洗前后结膜囊细菌培养阳性率、对眼表的毒副作用及术后眼内炎的发生率。结果实验组与对照组细菌培养阳性率差异有统计学意义；对眼表的影响无统计学差异；实验组无眼内炎发生，对照组发生2例眼内炎。结论应用0．5％聚维酮碘冲洗结膜囊可明显降低结膜囊细菌培养阳性率，且对眼表无明显不良反应，可替代妥布霉素用于老年性白内障术前结膜囊冲洗。“,”Objective To explore whether the irrigation of conjunctival sac using 0.5%povidone-iodine would prevent endophthalmitis after cataract surgery.Methods A total of 4 000 patients underwent cataract surgeries in our hospital from October 2012 to October 2013 were randomly enrolled in this study.All were divided into two groups:the experi-mental group and the control group.The experimental group used 0.5% povidone-iodine for conjunctiva sac irrigation before surgery and the control group used tobramycin.The bacterial rate of the conjunctival sac,the ocular surface side effects and post-operative endophthalmitis incidence were evaluated.Results The bacterial rate had statistically signifi-cant difference between the two groups (P0.05);There was no intraocular inflammation appeared in the experimental group,however,two cases of endophthalmitis occurred in the control group.Conclusion Tobramycin could be replaced by 0.5% povidone-iodine for pre-operative irrigation of conjunctival sac.