胆石病发病率较高,常见的胆石是胆固醇结石(CS)和胆色素结石(PS)。胆石病的临床治疗主要采用手术疗法,资料表明,胆囊切除术是不可取的,术后残石率,并发症和复发率均较高。本文就国内外的胆石溶解药物作一简介。1 口服溶石药物1.1 鹅去氧胆酸(CDCA)Salen 等认为口服CDCA 可扩大胆酸池,降低胆固醇饱和度,抑制肝内β-羟-β-甲基戍二酸单酰辅酶A-还原酶的活性,减少胆固 The incidence of gallstone disease is higher, the common gallstone is cholesterol (CS) and gallstone (PS). Cholelithiasis clinical treatment mainly by surgical treatment, data show that cholecystectomy is not desirable, postoperative residual stone rate, complications and recurrence rates were high. In this paper, a brief introduction of gallstone dissolution drugs at home and abroad. 1 Oral Limestone Drugs 1.1 Cortisone (CDCA) Salen et al believe that oral CDCA can expand the cholic acid pool, reduce cholesterol saturation, inhibit intrahepatic β-hydroxy-β-methyl glutaryl coenzyme A-reduction Enzyme activity, reduce the gall