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目的:探讨血清腹腔脂肪型丝氨酸蛋白酶抑制剂(Vaspin)水平与冠状动脉粥样硬化性心脏病的类型及病变程度的关系。方法:选择湖南师范大学附属第一医院心内科2015年11月~2016年11月入院拟诊为冠心病患者118例,根据临床症状、相关诊断标准及冠状动脉造影术检查,分成急性冠脉综合症(ACS)组37例、稳定型心绞痛(SAP)组51例和无冠心病组30例;采用酶联吸附法(ELISA)测定血清vaspin浓度,分析血清vaspin与冠心病的相关性。结果:急性冠脉综合症(ACS)组(0.66±0.44)ng/mL和稳定型心绞痛(SAP)组(0.86±0.37)ng/mL血清vaspin浓度显著低于无冠心病组(1.27±0.37)ng/mL;多元Logistic回归分析显示低血清vaspin水平是冠心病发病的独立危险因素。结论:冠心病患者血清vaspin水平较低,且血清vaspin水平与冠心病的发病及病变程度有关。
Objective: To investigate the relationship between the level of serum adiponectin (Vaspin) and the severity of coronary atherosclerotic heart disease. Methods: 118 cases admitted to the First Affiliated Hospital of Hunan Normal University from November 2015 to November 2016 were enrolled as CHD patients. According to clinical symptoms, related diagnostic criteria and coronary angiography, they were divided into acute coronary syndrome 37 cases of ACS, 51 cases of stable angina pectoris (SAP) group and 30 cases of non-CHD group. Serum vaspin concentration was determined by enzyme linked immunosorbent assay (ELISA), and the correlation between serum vaspin and coronary heart disease was analyzed. Results: Serum vaspin concentrations in ACS group (0.66 ± 0.44) ng / mL and SAP group (0.86 ± 0.37) ng / mL were significantly lower than those in non-CHD group (1.27 ± 0.37) multivariate logistic regression analysis showed that low serum vaspin level was an independent risk factor for coronary heart disease. Conclusion: The level of vaspin in patients with coronary heart disease is low, and the level of serum vaspin is related to the incidence and severity of coronary heart disease.