论文部分内容阅读
目的:考察自微乳载药系统(SMEDDS)对丹参酮的增溶和吸收的影响,以指导丹参酮SMEDDS处方的选择。方法:紫外分光光度法测定SMEDDS溶液中丹参总酮的溶解度,采用大鼠在体小肠吸收模型考察丹参酮SMEDDS的吸收。结果:丹参总酮在SMEDDS溶液中的溶解度是水中的10倍,胶束中的2.5倍,且SMEDDS处方中油相(中链甘油三酸酯,MCT)比例增加,溶解度增加;丹参酮SMEDDS和胶束的吸收常数Ka分别为0.479,0.326h-1,t1/2分别为1.44,2.12h,SMEDDS处方中油相(MCT)比例增加,吸收增加。结论:SMEDDS能显著增加丹参酮的溶解度和在大鼠小肠的吸收,且SMEDDS处方中MCT能促进丹参酮的增溶和吸收。
OBJECTIVE: To investigate the effect of self-microemulsion drug delivery system (SMEDDS) on the solubilization and absorption of tanshinone to guide the choice of tanshinone SMEDDS prescription. Methods: The solubility of tanshinone in SMEDDS solution was determined by UV spectrophotometry. The absorption of tanshinone SMEDDS was investigated in rat intestinal absorption model. Results: The solubility of total tanshinone in SMEDDS solution was 10 times higher than that in water and 2.5 times in micelles. The SMEDDS formulation increased the proportion of oil phase (medium chain triglyceride, MCT) and increased the solubility. Tanshinone SMEDDS and micelles The absorption constants Ka were 0.479,0.326h-1 and t1 / 2 were 1.44,2.12h respectively. The proportion of oil phase (MCT) in SMEDDS formulation increased and the absorption increased. Conclusion: SMEDDS can significantly increase the solubility of tanshinone and its absorption in rat intestine, and MCT can promote the solubilization and absorption of tanshinone in SMEDDS prescription.