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目的观察无创正压通气联合可拉明治疗慢性阻塞性肺疾病(COPD)合并肺性脑病的治疗效果。方法 40例COPD合并肺性脑病患者随机分为2组,每组20例,对照组予常规治疗,治疗组在常规治疗基础上应用无创正压通气同时维持静脉滴注可拉明。比较2组患者的意识转清时间、住院时间、气管插管率、治疗前后动脉血气分析情况。结果治疗组治疗后意识转清时间和住院时间均较对照组明显缩短,2组比较均有显著性差异(P<0.01);治疗组治疗后气管插管率较对照组明显减少,2组比较有显著性差异(P<0.05);治疗组在治疗后6 h和24 h血气分析情况较对照组明显改善,2组比较有显著性差异(P<0.01)。结论在常规治疗COPD合并肺性脑病的基础上使用无创正压通气联用可拉明可以获得较好的治疗效果,能有效缩短患者意识转清时间和住院时间,降低气管插管率,迅速改善血气分析情况。
Objective To observe the therapeutic effect of noninvasive positive pressure ventilation combined with cilamine on patients with chronic obstructive pulmonary disease (COPD) and pulmonary encephalopathy. Methods Forty patients with COPD and pulmonary encephalopathy were randomly divided into two groups (n = 20 in each group). The control group was given routine treatment. The treatment group received non-invasive positive pressure ventilation while maintaining the intravenous infusion of cialis. Two groups of patients awareness of clearance time, hospital stay, endotracheal intubation rate, arterial blood gas analysis before and after treatment. Results After treatment, the time to consciousness clearing and hospital stay in treatment group were significantly shorter than those in control group (P <0.01). The rate of tracheal intubation in treatment group was significantly lower than that in control group (P <0.05). The blood gas analysis at 6 h and 24 h after treatment in the treatment group was significantly improved compared with the control group. There was significant difference between the two groups (P <0.01). Conclusion The conventional treatment of COPD with pulmonary encephalopathy based on the use of noninvasive positive pressure ventilation combined with kalalamin can get better treatment, can effectively shorten the consciousness of patients and hospital stay time, reduce tracheal intubation rate, rapid improvement Blood gas analysis.