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目的:观察控释地诺前列酮(商品名欣普贝生)用于延期妊娠及过期妊娠引产的有效性及安全性。方法:回顾性分析2007—2010年我院98例延期及过期妊娠者,观察组48例,于阴道后穹窿放置控释地诺前列酮引产,对照组50例,静脉滴注催产素引产,应用统计学分析比较两组在给药前和给药后12h的宫颈Bishop评分,引产成功率,宫缩过强,胎儿窘迫,新生儿窒息,产后出血等情况。结果:两组病例在用药后12h宫颈评分比较,观察组明显优于对照组(P<0.01);观察组阴道分娩率高于对照组,剖宫产率低于对照组(P<0.01);两组发生宫缩过强情况,新生儿阿氏评分,产后出血差异无统计学意义(P>0.05)。结论:普贝生用于延期妊娠及过期妊娠引产效果优于催产素引产,并且无降低引产的安全性,是安全有效的引产药物。
OBJECTIVE: To observe the efficacy and safety of controlled release dinoprostone (trade name Hinbutsone) for delayed labor and induction of labor during expired pregnancy. Methods: A retrospective analysis of 98 cases of deferred and expired pregnancy in our hospital from 2007 to 2010, the observation group of 48 patients placed in the vaginal fornix controlled release dinoprostone induction of labor, the control group of 50 patients, intravenous infusion of oxytocin, application Statistical analysis of the two groups before and 12h after administration of cervical Bishop score, the success rate of induced labor, uterine contractions, fetal distress, neonatal asphyxia, postpartum hemorrhage and so on. Results: Compared with the control group, the vaginal delivery rate in the observation group was significantly higher than that in the control group (P <0.01). The vaginal delivery rate in the observation group was higher than that in the control group, and the cesarean section rate was lower than that in the control group (P <0.01). There was no significant difference between the two groups in the occurrence of uterine contractions, neonatal Asperger’s score and postpartum hemorrhage (P> 0.05). Conclusion: Przewalski ’s induction of labor for extended and overdue pregnancies is superior to oxytocin induction, and it is safe and effective to induce labor without reducing the safety of induced labor.