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自1968年Kimmel首先发现鸟纲胰多肽以来,人们已对6个种系的胰多肽结构进行了研究,发现它们的功能基均含有酪氨酸酰胺。在人体,胰多肽细胞位于胰岛的外周、腺泡以及中、小导管的上皮,大部见于胰头和钩突部,而少量见于胰体、尾部。进食后胰多肽的释放呈双相反应,在5分钟内其血浆浓度即升高4～6倍,持续30～60分钟,已知蛋白质和脂肪能刺激胰多肽的释放,迷走神经的胆硷能作用还起主要的调节作用;而后期的胰多肽释放是继发的,历时较长,它是胰泌素、胃泌素、胆囊收缩素、抑胃肽、血管活性肠多肽等激素以及迷走神经活动协同作用的结果,其中胆囊收缩旁更是主要
Since the first discovery of the avian pancreatic polypeptide by Kimmel in 1968, the structure of six pancreas polypeptides has been studied and found to contain tyrosine amides in their functional groups. In the human body, pancreatic polypeptide cells are located in the periphery of pancreatic islets, acinar and the epithelium of medium and small ducts, most of which are found in the head of the pancreas and the uncinate process, while a small amount is found in the body and tail of the pancreas. Postprandial pancreatic peptide release was biphasic reaction within 5 minutes that the plasma concentration increased 4 to 6 times for 30 to 60 minutes, it is known that protein and fat can stimulate the release of pancreatic polypeptide, vagal cholinergic effect But also play a major role in the regulation; and post-release of pancreatic polypeptide is secondary, lasted longer, it is secretin, gastrin, cholecystokinin, gastric inhibitory peptide, vasoactive intestinal polypeptide and other hormones and vagal activity coordination The role of the results, including gallbladder contraction is more important