心梗后,心脏迷走神经张力降低常伴有较高的死亡率,特别是猝死。在心脏急性缺血的动物模型中,刺激迷走神经有明显的抗心律失常作用。阿托品阻断周围有毒蕈碱受体导致心动过速,相反地小剂量阿托品产生短暂的心动过缓。本文研究心梗急性期经皮给予小剂量东茛菪碱能否引起心脏迷走神经张力和反射性输出的增高。 Myocardial infarction, cardiac vagal tone is often accompanied by lower tension, higher mortality, especially sudden death. In animal models of acute heart ischemia, there is a clear anti-arrhythmic effect of stimulating the vagus nerve. Atropine blocks muscarinic receptors around the heart that cause tachycardia, whereas low doses of atropine produce transient bradycardia. This study was to investigate whether acute administration of small doses of scopolamine in the acute phase of myocardial infarction can lead to an increase in cardiac vagal tone and reflex output.